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Search Results for " dihydroorotate dehydrogenase "

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抑制剂 & 化合物

1

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14501	BAY-2402234	Dehydrogenase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	BAY-2402234 是一种选择性二氢乳清酸脱氢酶的抑制剂，可研究骨髓恶性肿瘤。
T9394	CHIKV-IN-2	Dehydrogenase	Metabolism
	CHIKV-IN-2 基孔肯雅病毒的选择性抑制剂，具有强大的细胞抗病毒活性 (EC90=270 nM) 以及能够改善肝微粒体稳定性。它能够抑制细胞靶二氢乳清酸脱氢酶的活性。
T11546	hDHODH-IN-1	Dehydrogenase	Metabolism
	hDHODH-IN-1 是有效的人二氢乳清酸脱氢酶抑制剂，显示出抗炎作用。
T40168	DHODH-IN-16	Dehydrogenase	Metabolism
	DHODH-IN-16 是一种有效的二氢乳清酸脱氢酶抑制剂（DHODH，IC50 = 0.396 nM）。
T8767	PfDHODH-IN-2	Dehydrogenase; Parasite	Metabolism; Microbiology/Virology
	PfDHODH-IN-2 是一种二氢噻吩酮衍生物，是一种有效的恶性疟原虫二氢乳清酸脱氢酶抑制剂，其IC50值为 1.11 µM。它具有抗疟作用，可研究疟疾。
T11020	DHODH-IN-11	Dehydrogenase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	DHODH-IN-11 是一种来氟米特衍生物和弱二氢乳清酸脱氢酶 (DHODH) 抑制剂，pKa 为 5.03
T2601	Vidofludimus SC12267,4sc-101	Dehydrogenase; DNA/RNA Synthesis; Interleukin	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism
	Vidofludimus (SC12267) 是一种新型的二氢乳清酸脱氢酶 (DHODH) 小分子抑制剂，可在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。
T9121	AG-636	Dehydrogenase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	AG-636 是一种选择性可逆和具有口服活性的二氢乳清酸脱氢酶(DHODH)抑制剂，IC50 为 17 nM，具有很强的抗癌作用。
T13774	ML390	Others; Dehydrogenase	Metabolism; Others
	ML390 是二氢乳清酸脱氢酶抑制剂。他是骨髓分化的诱导剂，能够引起鼠 (ER-HoxA9) 以及人 (U937 and THP1) 急性髓细胞性白血病 (AML) 细胞发生骨髓分化。
T1919	Tenovin-1 Tenovin 1	Mdm2; Dehydrogenase; Sirtuin; p53; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-1 抑制 SirT1 和 SirT2 的蛋白质去乙酰化活性，并防止 MDM2 介导的 p53 降解，这涉及泛素化。它具有癌症的研究潜力。
T8480	Tenovin-6 Hydrochloride	Dehydrogenase; Sirtuin; HDAC; p53; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-6 Hydrochloride 是 Tenovin-1 的类似物，能抑制二氢乳清酸脱氢酶。它是一种 p53转录活性的激活剂，抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC50分别为 21 μM、10 μM 和 67 μM。
T1818	Tenovin-6 Tenovin 6	Dehydrogenase; Sirtuin; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism
	Tenovin-6 是 Tenovin-1 的类似物，能抑制二氢乳清酸脱氢酶。它也抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性，IC50分别为 21 μM、10 μM 和 67 μM。它是一种 p53转录活性的激活剂。
T5013	Brequinar Bipenquinate,NSC 368390,DUP785,布喹那	Virus Protease; Dehydrogenase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology
	Brequinar (NSC-368390) 是二氢乳清酸脱氢酶的一种强效抑制剂，对广谱病毒具有强效活性。
T1159	Leflunomide SU101,RS-34821,HWA486,来氟米特	Others; Dehydrogenase; AhR	Immunology/Inflammation; Metabolism; Others
	Leflunomide (HWA486) 是嘧啶合成抑制剂，能够抑制二氢乳清酸脱氢酶，具有抗风湿的活性。
T10384	Farudodstat ASLAN003	Apoptosis; Dehydrogenase; DNA/RNA Synthesis	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Farudodstat (ASLAN003) 是一种具有口服活性的二氢乳清酸脱氢酶 (DHODH) 抑制剂，对人 DHODH 酶的IC50为 35 nM。它通过激活 AP-1 转录因子来抑制蛋白质合成，可以诱导凋亡，并在急性髓样白血病异种移植小鼠中大大延长其生存期。
T12574	PTC299 Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate	VEGFR; Dehydrogenase	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) 是一种口服活性的 VEGFA mRNA 翻译抑制剂，可选择性地抑制转录后水平的 VEGF 蛋白合成。它还是二氢乳酸脱氢酶 (DHODH) 的有效抑制剂，可研究血液系统恶性肿瘤。
T11029	hDHODH-IN-5 DHODH-IN-7	Dehydrogenase	Metabolism
	hDHODH-IN-5 是人源二氢乳清酸脱氢酶的抑制剂 (hDHODH, IC50 = 0.91 μM)。
T11025	hDHODH-IN-3 DHODH-IN-2	Dehydrogenase	Metabolism
	hDHODH-IN-3 是人二氢乳清酸脱氢酶的抑制剂，pMIC50 值为 8.6。 hDHODH-IN-3 可以抑制麻疹病毒的复制。
T11019	DHODH-IN-1	Dehydrogenase	Metabolism
	DHODH-IN-1 是一种有效的 DHODH 抑制剂 (IC50 = 25 nM) 并抑制嘧啶生物合成途径。
T8332	Bipenquinate	Dehydrogenase	Metabolism
	Bipenquinate 是一种有效的、选择性的二氢乳清酸脱氢酶 (DHODH) 抑制剂，IC50 为 20 nM，阻断嘧啶的从头生物合成。
T11030	DHODH-IN-8	Dehydrogenase	Metabolism
	DHODH-IN-8 是一种人和恶性疟原虫二氢乳清酸脱氢酶的抑制剂，IC50 分别为 0.13 μM 和 47.4 μM，Ki 分别为 0.016 μM 和 5.6 μM。DHODH-IN-8 具有抗疟疾能力。
T11027	DHODH-IN-4	Dehydrogenase	Metabolism
	DHODH-IN-4 是人和 Plasmodium falciparum 二氢乳清酸脱氢酶 (DHODH) 的抑制剂，其对 PfDHODH 和 HsDHODH 的IC50 值分别为 4 μM 和 0.18 μM。DHODH-IN-4 (compound 17) 具有抗疟疾活性。
T11023	DHODH-IN-14	Dehydrogenase	Metabolism
	DHODH-IN-14是一种 A771726 的 hydroxyfurazan 类似物。DHODH-IN-14 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂，对大鼠肝脏 DHODH 的 IC50 为 0.49 μM。DHODH-IN-14 可用于类风湿关节炎。
T12438	PfDHODH-IN-1	Dehydrogenase; Parasite	Metabolism; Microbiology/Virology
	PfDHODH-IN-1 是 Leflunomide 活性代谢物的类似物，具有抗疟疾活性。它是恶性疟原虫二氢乳清酸脱氢酶抑制剂。
T11024	DHODH-IN-15	Dehydrogenase	Metabolism
	DHODH-IN-15是一种 A771726 的 hydroxyfurazan 类似物。DHODH-IN-15 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂，对大鼠肝脏 DHODH 的 IC50 为 11 μM。DHODH-IN-15 可用于类风湿关节炎。
T25353	DSM74 DSM 74,DSM-74
	DSM74 is a metabolically stable dihydroorotate dehydrogenase inhibitor that has antimalarial activity.
T71061	DSM267
	DSM267 is a novel Plasmodium falciparum Dihydroorotate Dehydrogenase (PfDHODH) Inhibitor.
T25448	Genz-669178
	Genz-669178 is a wild-type inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
T40087	DSM502
	DSM502, a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor, demonstrates potent nanomolar activity against Plasmodium DHODH and Plasmodium parasites, while not inhibiting mammalian DHODHs.
T68343	PyrD-IN-14
	PyrD-IN-14 is an inhibitor of the PyrD protein (a dihydroorotate dehydrogenase (DHODase) involved in pyrimidine biosynthesis) which suppresses bacterial cytotoxicity, biofilm formation, and antibiotic resistance.
T27498	GSK983 GSK-983,GSK 983
	GSK983, a potent broad-spectrum antiviral, blocks cell proliferation and dengue virus replication by inhibiting the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH).
T14780	BRD9185	Dehydrogenase	Metabolism
	BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
T25524	IDI-3783
	IDI-3783 is a mutant-selective inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
T71865	DSM43
	DSM43 is a dihydroorotate dehydrogenase (DHODH) inhibitor. Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated target for malaria treatmen
T26900	BRD7539 BRD-7539,BRD 7539
	BRD7539B is a Dihydroorotate dehydrogenase (DHODH) inhibitor . RD7539 shows to target PfDHODH (IC50 = 0.033 μM) selectively over human (Hs) DHODH (IC50 > 50 μM).
T69421	Hydrolapachol
	Hydrolapachol is a novel potent and selective inhibitor of schistosoma mansoni dihydroorotate dehydrogenase (smdhodh)
T40291	DSM705 DSM705
	DSM705 is a pyrrole-based inhibitor of Dihydroorotate Dehydrogenase (DHODH). It demonstrates high potency in the nanomolar range against Plasmodium DHODH and Plasmodium parasites, while not interfering with mammalian DHODHs. DSM705 shows significant efficacy as an antimalarial compound.
T11026	DHODH-IN-3	Others	Others
	DHODH-IN-3 is an effective inhibitor of human dihydroorotate dehydrogenase (HsDHODH) with IC50 value of 261 nM. DHODH-IN-3 binds to the ubiquinone binding cavity in DHODH with a Kiapp of 32 nM. DHODH-IN-3 has the potential to treat malaria.
T11547	hDHODH-IN-2	Others	Others
	hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor with anti-inflammatory activity.
T60409	P1788
	P1788 是一种二氢乳清酸脱氢酶 (DHODH) 抑制剂，可诱导 DNA 损伤。
T40182	Ascochlorin A Acremochlorin A
	Ascochlorin A is a novel and potent hDHODH inhibitor ( K D = 3.29 μM) for treatment of triple-negative breast cancer.
T69743	MEDS433
	MEDS433 is a dihydroorotate dehydrogenase inhibitor (IC50 1.2 nM). MEDS433 inhibited the in vitro replication of hCoV-OC43 and hCoV-229E, as well as of SARS-CoV-2, at low nanomolar range. Notably, the anti-SARS-CoV-2 activity of MEDS433 against SARS-CoV-2 was also observed in kidney organoids generated from human embryonic stem cells.
T11813	Laflunimus HR325	Others	Others
	Laflunimus suppresses immunoglobulin (Ig) secretion, with IC50 values of 2.5 and 2 μM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor. Laflunimus is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus is an orally active inhibitor of dihydroorotate dehydrogenase (DHODH).
T62550	DSM705 hydrochloride
	DSM705 hydrochloride 是一种有效的抗疟化合物，是一种基于吡咯的二氢乳清酸脱氢酶 (DHODH) 抑制剂。DSM705 hydrochloride 对 PlasmodiumDHODH 和 Plasmodium 寄生虫显示出纳摩尔级作用，不抑制哺乳动物 DHODH。
T64360	hDHODH-IN-8	Dehydrogenase	Metabolism
	hDHODH-IN-8 是人二氢乳清酸脱氢酶 (hDHODH) 的有效抑制剂，IC50 为 16 nM。 hDHODH-IN-8 具有强大的抗增殖活性和优异的水溶性。hDHODH-IN-8具有研究肿瘤疾病特别是淋巴瘤的潜力。
T82223	hDHODH-IN-13
	hDHODH-IN-13是一种针对人二氢乳清酸脱氢酶(hDHODH)的抑制剂，具有IC50值为173.4 nM。该化合物可应用于炎症性肠病(IBD)的研究。
T72948	hDHODH-IN-11
	hDHODH-IN-11 是一种有效的人二氢旋转酸脱氢酶 (hDHODH) 抑制剂，其 IC50值为 7.2 nM。hDHODH-IN-11具有低细胞毒性。hDHODH-IN-11 可用于急性髓系白血病 (AML) 的研究。
T70899	Vidofludimus hemicalcium 4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium
	Vidofludimus (4sc-101 ; SC12267) hemicalcium 是一种口服有效的二氢乳清酸脱氢酶 (DHODH) 的抑制剂，也是法尼醇 X 受体 (FXR) 调节剂。Vidofludimus hemicalcium 作为一种免疫调节剂，可用于研究自身免疫性疾病，如炎症性肠病 (IBD)。Vidofludimus hemicalcium 还可通过靶向FXR 用于脂肪肝的研究。
T78932	hDHODH-IN-12	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	hDHODH-IN-12是一种有效的DHODH抑制剂，IC50值为0.421 μM，DHODH作为嘧啶从头合成的限速酶，在(DNA/RNA Synthesis)DNA与RNA生成中扮演重要角色。hDHODH-IN-12位于人类线粒体内膜，展示了研究肺癌的潜力。
T72696	UCK2 Inhibitor-3
	UCK2 Inhibitor-3是一款UCK2 (尿苷胞苷激酶2)的非竞争性抑制剂，其IC50值为16.6 μM。该化合物能在一定程度上补偿因感染或快速分裂的细胞中DHODH (二氢旋酸脱氢酶)功能的缺失，有效地挽救尿苷。此外，UCK2 Inhibitor-3还能抑制DNA聚合酶η和κ，其IC50值分别为56 μM和16 μM。

化合物

Cat.No: T14501

Target: Dehydrogenase, DNA/RNA Synthesis

Cat.No: T9394

Target: Dehydrogenase

Cat.No: T11546

Target: Dehydrogenase

Cat.No: T40168

Target: Dehydrogenase

Cat.No: T8767

Target: Dehydrogenase, Parasite

Cat.No: T11020

Target: Dehydrogenase, DNA/RNA Synthesis

Cat.No: T2601

Synonym: SC12267,4sc-101

Target: Dehydrogenase, DNA/RNA Synthesis, Interleukin

Cat.No: T9121

Target: Dehydrogenase, DNA/RNA Synthesis

Cat.No: T13774

Target: Others, Dehydrogenase

Cat.No: T1919

Synonym: Tenovin 1

Target: Mdm2, Dehydrogenase, Sirtuin, p53, Autophagy

Tenovin-6 Hydrochloride

Cat.No: T8480

Target: Dehydrogenase, Sirtuin, HDAC, p53, Autophagy

Cat.No: T1818

Synonym: Tenovin 6

Target: Dehydrogenase, Sirtuin, Autophagy

Cat.No: T5013

Synonym: Bipenquinate,NSC 368390,DUP785,布喹那

Target: Virus Protease, Dehydrogenase, DNA/RNA Synthesis

Cat.No: T1159

Synonym: SU101,RS-34821,HWA486,来氟米特

Target: Others, Dehydrogenase, AhR

Cat.No: T10384

Synonym: ASLAN003

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis

Cat.No: T12574

Synonym: Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate

Target: VEGFR, Dehydrogenase

Cat.No: T11029

Synonym: DHODH-IN-7

Target: Dehydrogenase

Cat.No: T11025

Synonym: DHODH-IN-2

Target: Dehydrogenase

Cat.No: T11019

Target: Dehydrogenase

Cat.No: T8332

Target: Dehydrogenase

Cat.No: T11030

Target: Dehydrogenase

Cat.No: T11027

Target: Dehydrogenase

Cat.No: T11023

Target: Dehydrogenase

Cat.No: T12438

Target: Dehydrogenase, Parasite

Cat.No: T11024

Target: Dehydrogenase

Cat.No: T25353

Synonym: DSM 74,DSM-74

Cat.No: T71061

Cat.No: T25448

Cat.No: T40087

Cat.No: T68343

Cat.No: T27498

Synonym: GSK-983,GSK 983

Cat.No: T14780

Target: Dehydrogenase

Cat.No: T25524

Cat.No: T71865

Cat.No: T26900

Synonym: BRD-7539,BRD 7539

Cat.No: T69421

Cat.No: T40291

Synonym: DSM705

Cat.No: T11026

Target: Others

Cat.No: T11547

Target: Others

Cat.No: T60409

Cat.No: T40182

Synonym: Acremochlorin A

Cat.No: T69743

Cat.No: T11813

Synonym: HR325

Target: Others

DSM705 hydrochloride

Cat.No: T62550

Cat.No: T64360

Target: Dehydrogenase

Cat.No: T82223

Cat.No: T72948

Vidofludimus hemicalcium

Cat.No: T70899

Synonym: 4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium

Cat.No: T78932

Target: DNA/RNA Synthesis

UCK2 Inhibitor-3

Cat.No: T72696

Cat. No.	Product Name	Target	Signaling Pathways
T4880	L-Dihydroorotic acid	Others; Endogenous Metabolite	Metabolism; Others
	L-Dihydroorotic acid 是一种能够通过二氢乳清酶，能够逆水解产生的无环 L-脲基琥珀酸。

天然产物

L-Dihydroorotic acid

Cat.No: T4880

Target: Others, Endogenous Metabolite

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